Helping more than 55+ Countries

OUR EFFORTS TOWARDS SUFFERING HUMANITY TO

FIGHT AGAINST HIV

Clinically tested, Once a day, plant-based formulation designed to reduce HIV RNA (plasma viremia) & Proviral DNA (latent reservoir) , restores immunity, and prevents drug resistance.

PRESENTING THE NEW

HOO-IMM PLUS OD

A breakthrough once-a-day plant-based HIV treatment designed to inhibits viral replication, reduce RNA viral load, and support immune recovery.

Clinically tested with advanced dual-action on Integrase and Reverse Transcriptase enzymes, it helps restore CD4 T-cells and reduces intact provirus. With no virologic failure and consistent viral decay, HOO-IMM PLUS-OD is a promising, natural approach to long-term HIV management. Backed by research. Trusted by patients. Powered by nature.

Immuno Modulator

A drug that regulates the immune response. HOO-IMM PLUS OD helps to restore the balance of the immune system by restoring the CD4 T-cells in HIV patient which is otherwise low due to viral attack. The treatment regulates 10-20 % of overall CD4 T-cells.

No Virologic Failure

ARVs inability to long term suppress the virus results in increase in viral RNA load. “The No Virologic Failure” ability of HOOIMM PLUS-OD effectively results the patient’s viral load at undetectable level; a positive outcome of patient receiving HOOIMM PLUS-OD over ARVs.

About the Treatment

What is HOO-IMM PLUS OD?

HOO-IMM PLUS-OD is an advanced once-a-day herbal anti-HIV treatment, formulated by Hootone Remedies. It works by targeting two crucial HIV enzymes – Integrase (IN) and Reverse Transcriptase (RT) – responsible for HIV replication and integration. This leads to:

✅ 100% Plant-Based | ✅ Safe for Long-Term Use | ✅ Clinically Tested

How HOO-IMM PLUS-OD Works Over Time

About the Month-by-Month Progress Toward Viral Clearance and Immune Restorationeatment

Month 1 to 3: Blocking HIV Replication at Its Roots

In the first three months, HOO-IMM PLUS-OD begins its dual-action mechanism by targeting two of the most critical enzymes in the HIV life cycle — Reverse Transcriptase (RT) and Integrase (IN).

These enzymes are essential for the virus to multiply and integrate itself into the human genome. HOO-IMM PLUS-OD contains potent plant-based actives that inhibit RT, preventing the conversion of viral RNA into DNA, and inhibit IN, stopping viral DNA from inserting itself into your healthy immune cells.

During this phase, patients typically observe a gradual reduction in HIV RNA viral load, and the rate of new infections in CD4 T-cells drops significantly.

Unlike traditional ARVs, which only suppress the virus temporarily, HOO-IMM PLUS-OD begins reducing the actual reservoir of virus by preventing its spread at a molecular level.

Month 4 to 6: Immune Modulation & CD4 Cell Recovery Begins

Once viral replication slows down, HOO-IMM PLUS-OD starts supporting the immune system’s natural rebuilding process. It works as a powerful immune modulator, encouraging the regeneration of CD4 T-cells — the body’s primary defense against infections. This is especially important in HIV-positive individuals, where the immune system is weakened due to years of viral assault.

 

You’ll begin to notice a measurable increase in CD4 counts, and a balanced CD4/CD8 ratio, which indicates that your immune system is regaining control.

 

Additionally, patients report improved energy levels, reduced frequency of opportunistic infections (OIs), and better overall quality of life. Blood tests during this time will often show an improved immune profile and a more stabilized viral load.

Month 7 to 9: Targeting the Latent HIV Reservoir (Proviral DNA)

HIV has the unique ability to hide in the form of Proviral DNA, a latent form embedded in your immune cells. ARV therapy does not affect this latent reservoir, which is why it can’t cure HIV.

 

However, HOO-IMM PLUS-OD specifically targets the 3’ processing site of the HIV integrase enzyme, disrupting the virus’s ability to maintain this hidden state.

 

During this period, lab results typically reveal a decline in HIV Proviral DNA load — the true indicator of long-term HIV infection. Patients undergoing tests like HIV Proviral DNA PCR (Qualitative & Quantitative) will start seeing lower numbers, signifying that the integrated virus is being dismantled. This phase is a major turning point toward a functional HIV cure.

Month 10 to 12: Moving Toward a Functional Cure

In the final phase, HOO-IMM PLUS-OD’s cumulative effects lead to a sustained inhibition of the virus and eradication of latent reservoirs. Most patients who follow the protocol diligently record “Not Detected” results in HIV Proviral DNA PCR tests, confirming that HIV genetic material is no longer present in the body.

Once the HIV Proviral DNA becomes undetectable, the patient is considered functionally cured and can discontinue all HIV medications, including ARVs and HOO-IMM PLUS-OD, under medical supervision. These last few months are vital to ensure that the viral reservoir is completely eliminated, and your immune system is stable and self-sufficient.

Scientific Evidence

Clinically & Scientifically Proven

IC50 Value

0.95 µM (Lower than leading ARV: EFA = 1.472 µM)

Tested With

HIV-1 Reverse Transcriptase Assay (Xpress Bio, USA)

Result

98% inhibition observed in in-vitro HIV replication studies

Inhibits

3' Processing of Integrase (Prevents HIV DNA Integration)

Who Can Take HOO-IMM PLUS-OD?

A Treatment Suitable for All HIV Patients

HOO-IMM PLUS-OD is a universal solution designed for all stages of HIV infection. Whether you’re newly diagnosed or living with HIV for years, this once-a-day formula supports a safe, natural path to immune recovery and viral inhibition.

It’s especially beneficial for patients facing issues like drug resistance, poor CD4 count response, or adverse effects from ARVs.

Who can start the treatment?

The Smart Choice in the Path Toward HIV Functional Cure

Why Patients Choose HOO-IMM PLUS-OD?

HOO-IMM PLUS-OD has emerged as a revolutionary treatment option in the fight against HIV — not just because it’s effective, but because it’s designed with the real needs of patients in mind. Unlike standard ARV therapies that only suppress the virus temporarily, HOOIMM PLUS-OD takes a holistic, scientifically-backed approach: it inhibits both HIV replication and integration, regenerates immune function, and actively reduces HIV’s hidden form — the proviral DNA. With its once-a-day dosing, natural formulation, and zero reported virologic failures, patients find HOOIMM PLUS-OD easy to follow and deeply transformative. It’s not just about managing HIV.

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PRECLINICAL & CLINICAL OUTCOME

Explore Our

Awards and Achievements

Global Award 2018

Hakim Ajmal Khan Global Award

World Unani Day 2017

Best Unani Innovative Treatment

Intl Excellence Award 2012

In Dubai

Global Award 2014

Best Drug Manufacturer

Outcome of the earlier version of HOO-IMM PLUS

Patient Testimonials

HIV Detected: 05/11/2002

Treatment Started: 10/11/2002

Record Not Detected for

HIV DNA PCR Test: 26/6/2004

HIV Detected: 03/11/2000

Treatment Started: 05/11/2002

Record Not Detected for

HIV DNA PCR Test: 12/7/2004

HIV Detected: 23/7/2003

Treatment Started: 29/6/2004

Record Not Detected for

HIV DNA PCR Test: 16/1/2006

HIV Detected: 18/5/2004

Treatment Started: 23/11/2005

Record Not Detected for

HIV DNA PCR Test: 23/6/2008

HIV Detected: 1/1/2007

Treatment Started: 19/06/2010

Record Not Detected for

HIV DNA PCR Test: 21/5/2013

HIV Detected: 9/7/2011

Treatment Started: 3/7/2013

Record Not Detected for

HIV DNA PCR Test: 20/6/2015

Having any queries?

Frequently Asked Questions

Does HIV cure possible?

HIV Cure only Possible – Making visible & inhibiting the latent viral reservoirs ie. HIV proviral DNA
3 Major steps towards HIV Cure:-

  1. Reasons why HIV has been such a difficult medical challenge.
  2. Any HIV cure requires finding viral reservoirs, “waking” them up, and making them visible for treatment.
  3. Making visible & inhibiting the latent viral reservoirs – HIV proviral DNA.

The patient records Not Detected for the foremost HIV test which is HIV Proviral DNA PCR Qualitative test, after completing the course of the New HOOIMM PLUS-OD treatment. The minimum period required for the patient in order to completely eliminate the HIV latent viral reservoir from the body so as to record Negative for HIV Proviral DNA PCR Antigen Test is 12 – 15 months because the treatment targets the HIV latent viral reservoir which is the integrated genetic material of the virus. HIV (Human immunodeficiency virus) a retrovirus is always in the state of a provirus.

When a retrovirus invades a cell, the RNA of the retrovirus is reverse-transcribed into DNA by reverse transcriptase, then inserted into the host genome by an integrase. Integration can result in a latent infection or a productive infection. In a productive infection, the provirus is transcribed into messenger RNA which directly produces new virus, which in turn will infect other cells. A latent infection results when the provirus is transcriptionally silent rather than active.

Pro-viral HIV DNA PCR Antigen Test is the foremost confirmatory test to identify the presence of HIV virus in the human body. It’s very sensitive which detects a single copy of HIV gag target DNA at near-theoretical frequency, typically with microgram yields of specific amplification product. All the major infection like TB, Swine Flu, and Hepatitis are confirmed only through DNA PCR Antigen Test. The Proviral HIV DNA PCR will never be recorded Not Detected unless there is not a single HIV viral antigen in the body and once recorded Negative that means the blood sample is absent for the presence of HIV. And once you are negative for the presence of HIV then you are a normal healthy person and will live a normal, healthy and productive life.

Once the patient records Negative for HIV Proviral DNA PCR Test then he will completely stop all the medication including HOOIMM PLUS-OD as well as ARVs.

The New HOOIMM PLUS-OD course is well suitable for the following patients:

1) Patient those are not under ARVs.

2) Patient those are already undergoing ARVs.

The New HOOIMM PLUS-OD medication will also help the patient with ARVs to increase their CD4 count and decrease in HIV RNA viral load count and most importantly the Latent HIV Viral Reservoir (HIV DNA Proviral load count) which is not at all targeted by the ARVs. If the patient has not started ART, then the patient does not required to start ARVS and only start HOOIMM PLUS-OD. The patient already undergoing ARVs can start the New HOOIMM PLUS-OD and continue taking ARVS maintaining a gap of 2 hour.

How long is the course of the treatment ?

The minimum period required for the patient in order to completely eliminate the HIV latent viral reservoir from the body so as to record Negative for HIV Proviral DNA PCR Antigen Test is 12 – 15 months because the treatment targets the HIV latent viral reservoir which is the integrated genetic material of the virus.

Biomarker or Test Protocol Involved in the Anti-HIV Treatment with HOOIMM PLUS-OD:

  • HIV RNA Quantification Viral load count.
  • CD4 / CD8 count
  • HIV Proviral DNA Quantitative & Qualitative Test

Note: Quantification of HIV reflects the viral load which plays a critical role in determining the phase of infection, deciding the treatment and determining the response to anti-viral treatment.

Your health conditions will be regularly monitored by our expert consulting doctors. For online doctor’s consultation for all your queries
email us on info@hootone.org.
You can call us on our Helpline No. +91 9594000093 to talk to our doctor and experts directly.
You can also whatsapp to us your query on +919594000093

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